The AP - 2 α transcription factor is required for the ganglioside GM 3 - stimulated transcriptional regulation of PTEN gene
نویسندگان
چکیده
a Molecular and Cellular Glycobiology Unit, Department of Biological Science, SungKyunKwan University, 300 Chunchun-Dong, Jangan-Gu, Suwon City, Kyunggi-Do 440-746, Korea. b Division of Molecular and Life Science, Hanyang University, 1271 Sa-1 dong, Sangnok-gu, Ansan, Kyunggi-Do 425-791, Korea. c Department of Biotechnology, Dong-A University, Hadan-Dong, Saha-Gu, Busan 604-714, Korea. d Proteome Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong-Gu, Daejeon 305-600, Korea.
منابع مشابه
The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene.
Ganglioside GM3 inhibits the growth of several cancer cells and induces cell cycle arrest by regulating cellular signal pathways. Our previous results have shown that GM3 suppresses tumor suppressor PTEN-mediated cancer cell proliferation. However, the precise molecular mechanism(s) for the transcriptional regulation of a PTEN gene induced by GM3 remains unclear. Here, we show, for the first ti...
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